Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288812 | 0.99 | FLT3 (0.79) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5453222 | 0.89 | FLT3 (1.00) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8290936 | 0.89 | FLT3 (0.82) | FLT3MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5460296 | 0.85 | FLT3 (0.80) | FLT3MEN1KMT2AMAPTRXFP1 | |
| SCHEMBL3914715 | 0.84 | FLT3 (0.74) | FLT3MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL8289526 | 0.83 | RAB9A (0.95) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5455065 | 0.82 | MEN1 (0.79) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8289432 | 0.81 | KMT2A (1.00) | FLT3MEN1KMT2AALDH1A1RXFP1 | |
| SCHEMBL8290774 | 0.80 | KMT2A (0.98) | FLT3MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8289500 | 0.79 | RXFP1 (1.00) | FLT3MEN1KMT2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |