Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17861392 | 0.80 | MAP3K14 (0.38) | MTNR1AMAP3K14ITGB2ICAM1ITGAL | |
| SCHEMBL6582231 | 0.77 | MTNR1A (0.43) | MTNR1AMTNR1BITGB2ICAM1ITGAL | |
| SCHEMBL8374249 | 0.77 | MTNR1A (0.46) | MTNR1AMAP3K14MTNR1BITGB2ICAM1 | |
| SCHEMBL25707671 | 0.77 | MTNR1A (0.43) | MTNR1AMAP3K14MTNR1BITGB2ICAM1 | |
| SCHEMBL14188443 | 0.74 | MTNR1A (0.38) | MTNR1AMAP3K14MTNR1BMAPK1HSD17B10 | |
| SCHEMBL29565464 | 0.73 | CTNNB1 (0.41) | MTNR1AMTNR1BITGB2ICAM1ITGAL | |
| SCHEMBL29262317 | 0.73 | CTNNB1 (0.41) | MTNR1AMTNR1BITGB2ICAM1ITGAL | |
| SCHEMBL6582388 | 0.72 | MTNR1A (0.48) | MTNR1AMTNR1BSMN1; SMN2MAPK1HSD17B10 | |
| SCHEMBL8481752 | 0.72 | MTNR1A (0.48) | MTNR1AMTNR1BSMN1; SMN2MAPK1HSD17B10 | |
| SCHEMBL6583525 | 0.71 | MTNR1A (0.50) | MTNR1AMTNR1BSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005070460-A2 | COMBINATION THERAPY WITH 5-HT1A AND 5-HT1B RECEPTOR ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2005-08-04 | — | — | WO | disclosed |