Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 15/20 | 0.75 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.73 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31328289 | 0.85 | SIRT1 (0.75) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL1874310 | 0.85 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL29915361 | 0.85 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL8244015 | 0.85 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL1870769 | 0.85 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL4165081 | 0.85 | SIRT1 (0.75) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL1275557 | 0.85 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL8221609 | 0.84 | SIRT1 (0.73) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL8219990 | 0.84 | SIRT1 (0.73) | SIRT1SIRT2SIRT3RECQLALOX15 | |
| SCHEMBL251128 | 0.81 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005026112-A2 | METHODS OF TREATING A DISORDER | ELIXIR PHARMACEUTICALS, INC. (US) | 2005-03-24 | — | — | WO | disclosed |