Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.34 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13886148 | 0.95 | REN (0.33) | DRD2PRMT5WDR77RAMP1CALCRL | |
| SCHEMBL8278256 | 0.95 | REN (0.33) | DRD2PRMT5WDR77RAMP1CALCRL | |
| SCHEMBL13896342 | 0.90 | SCN9A (0.32) | DRD2ADRB3ADRA2BADRA2C | |
| SCHEMBL8165110 | 0.89 | DDB1 (0.34) | ADRB3ADRA2BADRA2C | |
| SCHEMBL13896394 | 0.89 | POLB (0.40) | POLBADRB3ADRA2BADRA2CALDH1A1 | |
| SCHEMBL12770115 | 0.89 | DDB1 (0.34) | ADRB3ADRA2BADRA2C | |
| SCHEMBL8295392 | 0.89 | ALDH1A1 (0.33) | POLBADRB3ADRA2BADRA2CALDH1A1 | |
| SCHEMBL8278885 | 0.88 | ADRB3 (0.33) | PRMT5WDR77POLBADRB3ADRA2B | |
| SCHEMBL3965585 | 0.86 | ADRB3 (0.46) | DRD2PRMT5WDR77BCL2RAMP1 | |
| SCHEMBL3975388 | 0.86 | ADRB3 (0.46) | DRD2PRMT5WDR77BCL2RAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037214-A2 | MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULFONAMIDES AS INHIBITORS OF HCV REPLICATION | INTERMUNE, INC. (US) | 2005-04-28 | — | — | WO | disclosed |