Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293267 | 0.79 | NPY1R (0.47) | SIGMAR1NPY1RHTTNPY2RSLC18A3 | |
| SCHEMBL21653769 | 0.74 | KMT2A (0.46) | OPRD1 | |
| SCHEMBL2851430 | 0.74 | KMT2A (0.46) | OPRD1 | |
| SCHEMBL21631693 | 0.74 | KMT2A (0.46) | OPRD1 | |
| SCHEMBL2851436 | 0.74 | KMT2A (0.46) | OPRD1 | |
| SCHEMBL12836223 | 0.73 | NPY1R (0.52) | SIGMAR1NPY1RHTTNPY2RSLC18A3 | |
| SCHEMBL1991966 | 0.70 | CYP2D6 (0.59) | SIGMAR1 | |
| SCHEMBL12836641 | 0.70 | NPY1R (0.43) | SIGMAR1NPY1RHTTNPY2RSLC18A3 | |
| SCHEMBL1318062 | 0.70 | LTA4H (0.52) | SIGMAR1NPY1RHTTNPY2R | |
| SCHEMBL14598757 | 0.69 | NPSR1 (0.55) | NPSR1HSD11B1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664031-B1 | ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | disclosed |
| WO-2005021536-A2 | ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS | SANOFI-AVENTIS (FR) | 2005-03-10 | — | — | WO | disclosed |