Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836223 | 0.83 | NPY1R (0.52) | NPY1RHTTNPY2RSIGMAR1SLC18A3 | |
| SCHEMBL8294455 | 0.79 | SIGMAR1 (0.42) | NPY1RHTTNPY2RSIGMAR1SLC18A3 | |
| SCHEMBL12836641 | 0.79 | NPY1R (0.43) | NPY1RHTTNPY2RSIGMAR1SLC18A3 | |
| SCHEMBL12836642 | 0.78 | HTR1A (0.50) | SIGMAR1 | |
| SCHEMBL1318062 | 0.76 | LTA4H (0.52) | NPY1RHTTNPY2RSIGMAR1ALDH1A1 | |
| SCHEMBL12178709 | 0.74 | KDM4E (0.40) | NPY1RHTTNPY2RSIGMAR1SLC18A3 | |
| SCHEMBL20310644 | 0.73 | HTR1A (0.49) | SIGMAR1LTA4H | |
| SCHEMBL17001730 | 0.73 | HTR1A (0.49) | SIGMAR1LTA4H | |
| SCHEMBL10895325 | 0.72 | SLC18A3 (0.53) | NPY1RHTTNPY2RSIGMAR1SLC18A3 | |
| SCHEMBL11015522 | 0.72 | SIGMAR1 (0.53) | NPY1RHTTNPY2RSIGMAR1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664031-B1 | ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | disclosed |
| WO-2005021536-A2 | ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS | SANOFI-AVENTIS (FR) | 2005-03-10 | — | — | WO | disclosed |