Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8294634 | 0.88 | ALDH1A1 (0.69) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL12929480 | 0.86 | ALDH1A1 (0.83) | MEN1KMT2AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL8295375 | 0.78 | ALDH1A1 (0.67) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL8297038 | 0.77 | ALDH1A1 (0.74) | MEN1KMT2AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL12929707 | 0.77 | ALDH1A1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL12929604 | 0.77 | ALDH1A1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL12929439 | 0.77 | MEN1 (0.72) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL5115261 | 0.75 | MEN1 (1.00) | MEN1KMT2AALDH1A1TDP1CYP1A2 | |
| SCHEMBL12929592 | 0.74 | ALDH1A1 (0.70) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL8294641 | 0.74 | ALDH1A1 (1.00) | MEN1KMT2AALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003099-A2 | PYRIMIDINES USEFUL AS MODULATORS OF VOLTAGE-GATED ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-01-13 | — | — | WO | disclosed |