Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8294743 | 0.86 | HDAC1 (0.76) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL8294741 | 0.80 | HDAC1 (0.49) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL8294749 | 0.78 | HDAC1 (0.44) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL13786320 | 0.77 | HDAC6 (0.76) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL26220123 | 0.73 | HDAC1 (0.48) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL1004150 | 0.71 | HDAC1 (1.00) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL1366970 | 0.71 | HDAC1 (1.00) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL1366844 | 0.70 | HDAC1 (1.00) | HDAC1HDAC10HDAC6HDAC8HDAC2 | |
| SCHEMBL13964720 | 0.67 | EPHX1 (0.50) | — | |
| SCHEMBL1365794 | 0.67 | HDAC1 (1.00) | HDAC1HDAC10HDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |