Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.37 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361832 | 0.71 | CRHR1 (0.52) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3361898 | 0.70 | JAK2 (0.44) | CRHR1HSD11B1F2RL3 | |
| Hydrochloric Acid SCHEMBL3364528 | 0.70 | CRHR1 (0.51) | CRHR1HSD11B1 | |
| SCHEMBL14206582 | 0.65 | HSD11B1 (0.36) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3364325 | 0.64 | NPC1 (0.42) | CRHR1HSD11B1 | |
| Hydrochloric Acid SCHEMBL3364477 | 0.63 | NPC1 (0.41) | CRHR1HSD11B1 | |
| SCHEMBL12856408 | 0.63 | HSD11B1 (0.54) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3365276 | 0.62 | NPC1 (0.43) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL12859298 | 0.61 | HSD11B1 (0.47) | CRHR1HSD11B1MMP12F2RL3 | |
| SCHEMBL12871630 | 0.60 | HSD11B1 (0.46) | CRHR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-B1 | GABANERGIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| WO-2005016892-A1 | GABANERGIC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-24 | — | — | WO | disclosed |