SCHEMBL8296191

SCHEMBL8296191

CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)OCc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CPB1 P15086 2/20 0.64
CTSB P07858 2/20 0.57
CTSS P25774 2/20 0.57
CTSK P43235 2/20 0.57
CTSL P07711 1/20 0.57
CASP3 P42574 3/20 0.56
TSHR P16473 1/20 0.51
EPHX1 P07099 1/20 0.51
ALDH1A1 P00352 2/20 0.50
GAA P10253 1/20 0.50
F9 P00740 2/20 0.49
F10 P00742 2/20 0.49
PRSS1 P07477 1/20 0.49
PRSS2 P07478 1/20 0.49
PRSS3 P35030 1/20 0.49
TAS1R3 Q7RTX0 2/20 0.49
TAS1R1 Q7RTX1 2/20 0.49
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28854927 1.00 CPB1 (0.64) CPB1CTSBCTSSCTSKCTSL
SCHEMBL10303639 0.90 CPB1 (0.78) CPB1CTSBCTSSCTSKCTSL
SCHEMBL4481541 0.90 CPB1 (0.78) CPB1CTSBCTSSCTSKCTSL
SCHEMBL28376595 0.90 CPB1 (0.78) CPB1CTSBCTSSCTSKCTSL
SCHEMBL26253812 0.89 CPB1 (0.76) CPB1CTSBCTSSCTSKCTSL
SCHEMBL13712268 0.88 CPB1 (0.78) CPB1CTSBCTSSCTSKCTSL
SCHEMBL14161287 0.88 CPB1 (0.78) CPB1CTSBCTSSCTSKCTSL
SCHEMBL5345577 0.87 CASP3 (0.62) CPB1CTSBCTSSCTSKCTSL
SCHEMBL22204568 0.87 CASP3 (0.62) CPB1CTSBCTSSCTSKCTSL
SCHEMBL6200837 0.87 CASP3 (0.62) CPB1CTSBCTSSCTSKCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7300934-B2 Benzamide nitriles ROCHE PALO ALTO LLC (US) 2007-11-27 US disclosed
US-7300934-B2 Benzamide nitriles ROCHE PALO ALTO LLC (US) 2007-11-27 US disclosed
EP-1453801-B1 SUBSTITUTED 2-AMINO-CYCLOALKANECARBOXAMIDES AND THEIR USE AS CYSTEINE PROTEASE INHIBITORS HOFFMANN LA ROCHE (CH) 2007-03-21 EP disclosed
WO-2004106285-A1 BENZAMIDE NITRILE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2004-12-09 WO disclosed