Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.54 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827030 | 0.90 | POLB (0.54) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL1826606 | 0.89 | IL2 (0.58) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL16363159 | 0.80 | TRPC3 (0.54) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL8263238 | 0.80 | LMNA (0.51) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL7972108 | 0.78 | LMNA (0.84) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL8261714 | 0.78 | LMNA (0.54) | TRPC3ORAI1TRPC5LMNACRACR2A | |
| SCHEMBL8261109 | 0.78 | LMNA (0.51) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL8260401 | 0.78 | LMNA (0.57) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL14881337 | 0.77 | LMNA (0.53) | POLBTRPC3ORAI1TRPC5LMNA | |
| SCHEMBL5531239 | 0.76 | POLB (0.50) | POLBTRPC3ORAI1TRPC5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009539-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-02-03 | — | — | WO | disclosed |