Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480237 | 0.78 | ALDH1A1 (0.35) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23023223 | 0.77 | MEN1 (0.71) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL17598268 | 0.77 | MEN1 (0.71) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1549048 | 0.77 | MEN1 (0.71) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14762021 | 0.75 | HSD11B1 (0.40) | EPHX2ALDH1A1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL14762020 | 0.75 | HSD11B1 (0.40) | EPHX2ALDH1A1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL12936872 | 0.73 | HPGD (0.55) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8299816 | 0.73 | ALDH1A1 (0.48) | EPHX2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16658820 | 0.72 | MGAM (0.41) | EPHX2ALDH1A1SMN1; SMN2KMT2AP2RX7 | |
| SCHEMBL23460096 | 0.72 | MGAM (0.41) | EPHX2ALDH1A1SMN1; SMN2KMT2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553937-B1 | GLYCINENITRILE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | BRISTOL MYERS SQUIBB CO (US) | 2010-06-02 | — | — | EP | disclosed |
| EP-1658066-B1 | ADAMANTYLGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | BRISTOL MYERS SQUIBB CO (US) | 2009-09-30 | — | — | EP | disclosed |
| EP-1997489-A1 | Adamantylglycine derivatives as inhibitors of dipeptidyl peptidase IV for the treatment of diabetes | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2005012249-A2 | ADAMANTYGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-10 | — | — | WO | disclosed |
| WO-2004037181-A2 | GLYCINENITRILE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-05-06 | — | — | WO | disclosed |