Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297736 | 0.83 | MAPT (0.74) | MAPTLMNAKDM4EPOLBKMT2A | |
| SCHEMBL3751466 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL1472459 | 0.81 | EPHX2 (0.53) | ALDH1A1MAPTLMNAPOLBKMT2A | |
| SCHEMBL1471708 | 0.80 | EPHX2 (0.55) | ALDH1A1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL13148192 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL29791119 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAKDM4ETDP1 | |
| SCHEMBL27828442 | 0.77 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL12335437 | 0.77 | USP30 (0.49) | ALDH1A1MAPTKDM4ETDP1POLB | |
| SCHEMBL13148162 | 0.76 | ALDH1A1 (0.77) | ALDH1A1LMNAKDM4ETDP1POLB | |
| SCHEMBL7552286 | 0.76 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007621-A2 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | disclosed |