Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 16/20 | 0.76 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | ICMT | O60725 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962843 | 0.86 | PLA2G2A (1.00) | PLA2G2AMTNR1AMTNR1BICMT | |
| SCHEMBL8292273 | 0.85 | PLA2G2A (0.57) | PLA2G2AMTNR1AMTNR1BICMT | |
| SCHEMBL7965182 | 0.82 | PLA2G2A (1.00) | PLA2G2A | |
| SCHEMBL8298844 | 0.80 | PLA2G2A (1.00) | PLA2G2A | |
| SCHEMBL9096563 | 0.76 | PLA2G2A (0.80) | PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL7963252 | 0.76 | PLA2G2A (1.00) | PLA2G2AMTNR1AMTNR1BICMT | |
| SCHEMBL20769739 | 0.75 | PLA2G2A (0.83) | PLA2G2AMTNR1AMTNR1BICMT | |
| SCHEMBL8299582 | 0.75 | PLA2G2A (0.78) | PLA2G2AMTNR1AMTNR1BICMT | |
| SCHEMBL8292030 | 0.75 | PLA2G2A (0.77) | PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL4658955 | 0.72 | PLA2G2A (0.51) | PLA2G2AMTNR1AMTNR1BICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |