Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 1.00 |
| ▸ | ICMT | O60725 | 6/20 | 0.71 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | PPARD | Q03181 | 1/20 | 0.62 |
| ▸ | PPARA | Q07869 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769739 | 0.91 | PLA2G2A (0.83) | PLA2G2AICMTMTNR1AMTNR1BHTR6 | |
| SCHEMBL7962843 | 0.89 | PLA2G2A (1.00) | PLA2G2AICMTMTNR1AMTNR1BHTR6 | |
| SCHEMBL16494632 | 0.88 | PLA2G2A (0.78) | PLA2G2AICMTMTNR1AMTNR1BHTR6 | |
| SCHEMBL8924309 | 0.87 | PLA2G2A (0.77) | PLA2G2AICMTMTNR1AMTNR1BPPARG | |
| SCHEMBL8290865 | 0.85 | PLA2G2A (0.74) | PLA2G2AICMTMTNR1AMTNR1BHTR6 | |
| SCHEMBL7962690 | 0.85 | PLA2G2A (0.74) | PLA2G2AICMTMTNR1AMTNR1BHTR6 | |
| SCHEMBL12083183 | 0.85 | PLA2G2A (0.74) | PLA2G2AICMTMTNR1AMTNR1BHTR6 | |
| SCHEMBL8926520 | 0.85 | PLA2G2A (0.74) | PLA2G2AICMTMTNR1AMTNR1B | |
| SCHEMBL8924312 | 0.84 | PLA2G2A (0.72) | PLA2G2AICMTMTNR1AMTNR1BPPARG | |
| SCHEMBL3019384 | 0.84 | MTNR1A (0.73) | PLA2G2AMTNR1AMTNR1BHTR6PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |