Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 4/20 | 0.65 |
| ▸ | PPARG | P37231 | 3/20 | 0.65 |
| ▸ | PPARA | Q07869 | 3/20 | 0.65 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.60 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.58 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.58 |
| ▸ | ICMT | O60725 | 3/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27386831 | 0.90 | LTB4R (0.64) | PPARDPPARGPPARAPLA2G2ALTB4R | |
| SCHEMBL13931028 | 0.90 | PPARG (0.56) | PPARDPPARGPPARAPLA2G2ALTB4R | |
| SCHEMBL7962690 | 0.89 | PLA2G2A (0.74) | PPARDPPARGPPARAPLA2G2AICMT | |
| SCHEMBL8290865 | 0.85 | PLA2G2A (0.74) | PPARDPPARGPPARAPLA2G2AICMT | |
| SCHEMBL13931042 | 0.84 | PPARD (0.58) | PPARDPPARGPPARAPLA2G2ALTB4R | |
| SCHEMBL7962123 | 0.84 | PLA2G2A (0.64) | PPARDPPARGPPARAPLA2G2AICMT | |
| SCHEMBL7962127 | 0.84 | PLA2G2A (0.66) | PPARDPPARGPPARAPLA2G2AICMT | |
| SCHEMBL8299582 | 0.83 | PLA2G2A (0.78) | PPARDPPARGPPARAPLA2G2ALTB4R | |
| SCHEMBL7953555 | 0.82 | PLA2G2A (0.79) | PPARDPPARGPPARAPLA2G2AICMT | |
| SCHEMBL8166905 | 0.82 | PPARD (0.74) | PPARDPPARGPPARAPLA2G2ALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |