Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299842 | 0.85 | ITGB1 (0.43) | SMN1; SMN2KDM4EITGB1ITGA4ITGB7 | |
| SCHEMBL8297152 | 0.84 | MAPT (0.49) | SMN1; SMN2KDM4ENPC1RAB9ACASP3 | |
| SCHEMBL14603025 | 0.84 | ITGA4 (0.68) | SMN1; SMN2KDM4ENPC1RAB9ACASP3 | |
| SCHEMBL8297117 | 0.84 | ITGA4 (0.68) | SMN1; SMN2KDM4ENPC1RAB9ACASP3 | |
| SCHEMBL8297130 | 0.77 | ITGA4 (0.57) | SMN1; SMN2KDM4ENPC1RAB9ACASP3 | |
| SCHEMBL8297127 | 0.77 | ITGA4 (0.57) | SMN1; SMN2KDM4ENPC1RAB9ACASP3 | |
| SCHEMBL8298330 | 0.77 | ITGB1 (0.39) | SMN1; SMN2KDM4EITGB1ITGA4ITGB7 | |
| SCHEMBL8278642 | 0.76 | ITGA4 (0.79) | SMN1; SMN2KDM4ENPC1RAB9ACASP3 | |
| SCHEMBL14603020 | 0.72 | ITGB1 (0.74) | ITGB1ITGA4ITGB7 | |
| SCHEMBL14603021 | 0.72 | ITGB1 (0.68) | ITGB1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004103967-A2 | THIOCARBAMATE INHIBITORS OF ALPHA-4 INTEGRINS | GENENTECH, INC. (US) | 2004-12-02 | — | — | WO | disclosed |