Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 4/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 4/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14603018 | 0.86 | ITGB1 (0.61) | ITGB1ITGA4ITGB7SMN1; SMN2MEN1 | |
| SCHEMBL8299843 | 0.85 | SMN1; SMN2 (0.48) | ITGB1ITGA4ITGB7SMN1; SMN2MEN1 | |
| SCHEMBL8298330 | 0.79 | ITGB1 (0.39) | ITGB1ITGA4ITGB7SMN1; SMN2P2RX7 | |
| SCHEMBL14603023 | 0.73 | ITGB1 (0.46) | ITGB1ITGA4ITGB7MEN1KMT2A | |
| SCHEMBL8298334 | 0.71 | GRIN2C (0.45) | ALDH1A1 | |
| SCHEMBL8298342 | 0.71 | CHRM1 (0.39) | ITGB1ITGA4ITGB7KCNK3SMN1; SMN2 | |
| SCHEMBL8297152 | 0.70 | MAPT (0.49) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8297117 | 0.70 | ITGA4 (0.68) | ITGB1ITGA4ITGB7SMN1; SMN2MEN1 | |
| SCHEMBL14603025 | 0.70 | ITGA4 (0.68) | ITGB1ITGA4ITGB7SMN1; SMN2MEN1 | |
| SCHEMBL1307353 | 0.67 | KEAP1 (0.50) | SMN1; SMN2P2RX7KEAP1NFE2L2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004103967-A2 | THIOCARBAMATE INHIBITORS OF ALPHA-4 INTEGRINS | GENENTECH, INC. (US) | 2004-12-02 | — | — | WO | disclosed |