Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472641 | 0.95 | TP53 (0.47) | TP53CYP3A4MTNR1AMTNR1BTSHR | |
| Nitrogen SCHEMBL5663961 | 0.86 | TSHR (0.55) | MTNR1AMTNR1BTSHRTHRBTHRA | |
| SCHEMBL8295925 | 0.85 | TSHR (0.49) | MTNR1AMTNR1BTSHRTHRBKMT2A | |
| SCHEMBL31746156 | 0.84 | MTNR1A (0.63) | MTNR1AMTNR1B | |
| SCHEMBL11934278 | 0.83 | BCHE (0.55) | MEN1KMT2A | |
| SCHEMBL12862530 | 0.82 | ALDH1A1 (0.49) | TP53CYP3A4TSHRALDH1A1KDM4E | |
| SCHEMBL10890808 | 0.82 | CYP3A4 (0.47) | TP53CYP3A4MTNR1AMTNR1BTSHR | |
| SCHEMBL31339101 | 0.81 | ALDH1A1 (0.55) | TP53CYP3A4ALDH1A1KDM4ETHRB | |
| SCHEMBL1760671 | 0.81 | ALDH1A1 (0.55) | TP53CYP3A4ALDH1A1KDM4ETHRB | |
| SCHEMBL8664850 | 0.80 | MTNR1A (0.58) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568497-B1 | Chromogene methylenepyrrolins | CIBA GEIGY AG (CH) | 1999-07-07 | — | — | EP | disclosed |
| US-5387694-A | Chromogenic methylenepyrrolines | CIBA-GEIGY CORPORATION (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0568497-A1 | Chromogene methylenepyrrolins | CIBA-GEIGY AG (CH) | 1993-11-03 | — | — | EP | disclosed |