SCHEMBL8300214

SCHEMBL8300214

N#Cc1ccccc1C[N+](=O)[O-]

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.44
HPGD P15428 2/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
MAPT P10636 2/20 0.44
LMNA P02545 1/20 0.44
PKM P14618 1/20 0.44
MAPK1 P28482 1/20 0.44
HTT P42858 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
GPR55 Q9Y2T6 1/20 0.44
KMT2A Q03164 1/20 0.41
CYP19A1 P11511 2/20 0.40
POLB P06746 1/20 0.40
TSHR P16473 2/20 0.38
MCL1 Q07820 1/20 0.37
HSD11B1 P28845 1/20 0.37
FFAR1 O14842 1/20 0.36
SIRT2 Q8IXJ6 1/20 0.36
SIRT1 Q96EB6 1/20 0.36
TAS2R14 Q9NYV8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10722276 0.79 ALDH1A1 (0.46) ALDH1A1HPGDMAPTLMNAMAPK1
SCHEMBL8440818 0.74 ALDH1A1 (0.51) ALDH1A1HPGDSMN1; SMN2MAPTLMNA
SCHEMBL483553 0.73 CYP19A1 (0.46) ALDH1A1SMN1; SMN2MAPTHTTCYP19A1
SCHEMBL106062 0.73 TSHR (0.50) ALDH1A1SMN1; SMN2MAPTHTTCYP19A1
SCHEMBL2154210 0.72 SMN1; SMN2 (0.49) ALDH1A1HPGDSMN1; SMN2MAPTNPSR1
SCHEMBL2153612 0.72 CYP19A1 (0.48) ALDH1A1HPGDSMN1; SMN2MAPTNPSR1
Nitric Acid SCHEMBL27674412 0.71 TSHR (0.43) ALDH1A1HPGDSMN1; SMN2MAPTLMNA
SCHEMBL11229770 0.71 ALDH1A1 (0.41) ALDH1A1HPGDSMN1; SMN2MAPTLMNA
Ethane SCHEMBL2154770 0.71 TSHR (0.48) ALDH1A1SMN1; SMN2MAPTHTTCYP19A1
SCHEMBL19356915 0.70 CYP19A1 (0.47) ALDH1A1HPGDSMN1; SMN2MAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906285-A1 3-CYANOARYL PYRAZOLES AND USE THEREOF AS HERBICIDES BAYER AG (DE) 1999-04-07 EP claimed
WO-1997046535-A1 3-CYANOARYL PYRAZOLES AND USE THEREOF AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-11 WO claimed
EP-0128382-B1 1-ALKYL-2-ISOCYANATOMETHYL-ISOCYANATO-CYCLOHEXANES AND/OR 1-ALKYL-4-ISOCYANATO-METHYL-ISOCYANATO-CYCLOHEXANES AND THE LIKE DIAMINES, PROCESSES FOR THEIR PREPARATION, AND USE BASF Aktiengesellschaft (DE) 1989-09-27 EP disclosed
EP-0091054-B1 1-ALKYL-2-ISOCYANATOMETHYL-ISOCYANATO PHENYL AND/OR 1-ALKYL-4-ISOCYANATOMETHYL-ISOCYANATO PHENYL, METHOD FOR THEIR PREPARATION AND USE BASF Aktiengesellschaft (DE) 1985-10-02 EP disclosed
US-4512929-A POLYURETHANE MONOMERS, PLANT SAFENING AGENT BASF AKTIENGESELLSCHAFT (DE) 1985-04-23 US disclosed
EP-0128382-A1 1-Alkyl-2-isocyanatomethyl-isocyanato-cyclohexanes and/or 1-alkyl-4-isocyanato-methyl-isocyanato-cyclohexanes and the like diamines, processes for their preparation, and use BASF Aktiengesellschaft (DE) 1984-12-19 EP disclosed
EP-0091054-A1 1-Alkyl-2-isocyanatomethyl-isocyanato phenyl and/or 1-alkyl-4-isocyanatomethyl-isocyanato phenyl, method for their preparation and use BASF Aktiengesellschaft (DE) 1983-10-12 EP disclosed