Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLR1A | O95602 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8300274 | 0.92 | KEAP1 (0.50) | KEAP1PDPK1BCHEMAPTKDM4E | |
| SCHEMBL30088294 | 0.82 | KEAP1 (0.64) | KEAP1PDPK1BCHEMAPTKDM4E | |
| SCHEMBL28600150 | 0.82 | KEAP1 (0.64) | KEAP1PDPK1BCHEMAPTKDM4E | |
| SCHEMBL5486616 | 0.81 | KEAP1 (0.58) | KEAP1PDPK1BCHEMAPTKDM4E | |
| SCHEMBL8291239 | 0.78 | HDAC1 (0.59) | KEAP1PDPK1BCHEMAPTKDM4E | |
| SCHEMBL18937409 | 0.77 | KEAP1 (0.57) | KEAP1PDPK1BCHEMAPTKDM4E | |
| SCHEMBL8290881 | 0.76 | HDAC1 (0.63) | KEAP1PDPK1MAPTKDM4EPOLR1A | |
| SCHEMBL8290878 | 0.74 | KEAP1 (0.47) | KEAP1PDPK1BCHEMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7884796 | 0.73 | PDPK1 (0.59) | KEAP1PDPK1BCHEMAPTKDM4E | |
| SCHEMBL3790885 | 0.73 | KEAP1 (0.70) | KEAP1PDPK1BCHEMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330986-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-07-19 | — | — | US | claimed |
| EP-0599240-B1 | Indole-7-carboxamide derivatives as analgesics | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5330986-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0599240-A1 | Indole-7-carboxamide derivatives as analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-06-01 | — | — | EP | disclosed |