Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10469244 | 0.85 | POLB (0.44) | POLBOPRM1TSHRBRD4ATM | |
| SCHEMBL336317 | 0.75 | KDM4E (0.47) | POLBOPRM1ATMOPRD1KDM4E | |
| SCHEMBL2814112 | 0.74 | OPRM1 (0.54) | POLBOPRM1SLC22A1SLC6A4ADRA1A | |
| SCHEMBL4288590 | 0.74 | POLB (0.41) | POLBOPRM1BRD4ATMSLC22A1 | |
| SCHEMBL3147434 | 0.72 | POLB (0.46) | POLBOPRM1BRD4ATMSLC22A1 | |
| SCHEMBL24094554 | 0.72 | OPRM1 (0.47) | POLBOPRM1BRD4ATMSLC22A1 | |
| SCHEMBL18134201 | 0.71 | ALDH1A1 (0.46) | POLBOPRM1ATMSLC22A1SLC6A4 | |
| SCHEMBL69496 | 0.71 | ALDH1A1 (0.46) | POLBOPRM1ATMSLC22A1SLC6A4 | |
| SCHEMBL15624086 | 0.71 | OPRM1 (0.38) | POLBOPRM1BRD4SLC22A1SLC6A4 | |
| SCHEMBL18186029 | 0.71 | BRD4 (0.58) | POLBOPRM1TSHRBRD4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965578-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0897303-A4 | — | — | 1999-02-24 | — | — | EP | disclosed |
| EP-0897303-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-02-24 | — | — | EP | disclosed |
| WO-1997036605-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| US-4965371-A | Selective cyclization process | WHITBY RESEARCH, INC. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4870173-A | Lactam formation by a selective cyclization process | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-09-26 | — | — | US | disclosed |