Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 17/20 | 0.60 |
| ▸ | FNTB | P49356 | 17/20 | 0.60 |
| ▸ | PGGT1B | P53609 | 11/20 | 0.60 |
| ▸ | NRAS | P01111 | 1/20 | 0.54 |
| ▸ | HRAS | P01112 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503737 | 0.89 | FNTA (0.61) | FNTAFNTBPGGT1BNRASHRAS | |
| Hydrochloric Acid SCHEMBL7830288 | 0.83 | CYP11B1 (0.58) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7459721 | 0.79 | NPC1 (0.57) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL4586702 | 0.77 | ALDH1A1 (0.51) | — | |
| SCHEMBL7655240 | 0.77 | FNTA (0.84) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL8183619 | 0.77 | CYP11B1 (0.67) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8310406 | 0.75 | FNTA (0.66) | FNTAFNTBPGGT1BNRASHRAS | |
| Hydrochloric Acid SCHEMBL8420854 | 0.74 | FNTA (0.65) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7526455 | 0.74 | FNTA (0.66) | FNTAFNTBPGGT1BKCNH2 | |
| Hydrochloric Acid SCHEMBL7452379 | 0.73 | FNTA (0.65) | FNTAFNTBPGGT1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897303-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-02-24 | — | — | EP | disclosed |
| EP-0897303-A4 | — | — | 1999-02-24 | — | — | EP | disclosed |
| WO-1997036605-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |