Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SCN1A | P35498 | 3/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992907 | 0.88 | SCN1A (0.55) | HTTSCN1ASCN2ASCN3ASLC6A2 | |
| Dimethylamine SCHEMBL29198789 | 0.82 | HTT (0.55) | HTTSCN1ASCN2ASCN3ASLC6A2 | |
| Ethylene Glycol SCHEMBL27734001 | 0.80 | HTT (0.49) | HTTSCN1ASCN2ASCN3ASLC6A2 | |
| SCHEMBL7586879 | 0.78 | IDO1 (0.39) | HTTSCN1ASCN2ASCN3ASLC6A2 | |
| SCHEMBL27936077 | 0.77 | IDO1 (0.56) | HTTSCN1ASCN2ASCN3ASLC6A2 | |
| SCHEMBL6743965 | 0.77 | HTT (0.46) | HTTSCN1ASCN2ASCN3ASLC6A2 | |
| SCHEMBL1413359 | 0.75 | PTGS2 (0.44) | LMNAL3MBTL1 | |
| SCHEMBL668550 | 0.75 | HTR2A (0.46) | LMNACYP1A2TSHRHTR2AHRH1 | |
| SCHEMBL8678809 | 0.75 | SLC6A4 (0.35) | HTTSLC6A4LMNATSHRMEN1 | |
| SCHEMBL1628206 | 0.74 | LMNA (0.35) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579766-B1 | N-ARYLHETEROARYLALKYL IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 1999-06-02 | — | — | EP | claimed |