Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 10/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RGS12 | O14924 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952654 | 0.89 | PLA2G2A (0.82) | PLA2G2AKDM4EHSD17B10AKR1C3AKR1C2 | |
| SCHEMBL9371452 | 0.89 | PLA2G2A (0.82) | PLA2G2AKDM4EHSD17B10AKR1C3AKR1C2 | |
| SCHEMBL7964650 | 0.86 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL7961727 | 0.86 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL7963463 | 0.86 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL7953737 | 0.86 | PLA2G2A (1.00) | PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL8300469 | 0.83 | PLA2G2A (0.80) | PLA2G2AKDM4EHSD17B10AKR1C3AKR1C2 | |
| SCHEMBL7963668 | 0.83 | PLA2G2A (0.78) | PLA2G2AKDM4EHSD17B10PLA2G1BCNR2 | |
| SCHEMBL7962129 | 0.83 | PLA2G2A (0.78) | PLA2G2AKDM4EHSD17B10PLA2G1BCNR2 | |
| SCHEMBL7961629 | 0.83 | PLA2G2A (0.78) | PLA2G2AKDM4EHSD17B10PLA2G1BCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |