Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 2/20 | 0.69 |
| ▸ | TACR1 | P25103 | 2/20 | 0.69 |
| ▸ | CCR5 | P51681 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296084 | 0.89 | CCR5 (0.64) | TACR2TACR1CCR5 | |
| Hydrochloric Acid SCHEMBL8522900 | 0.89 | CCR5 (0.63) | TACR2TACR1CCR5 | |
| SCHEMBL8296058 | 0.88 | TACR2 (0.54) | TACR2TACR1CCR5 | |
| SCHEMBL9027933 | 0.88 | TACR1 (0.65) | TACR2TACR1CCR5HRH1 | |
| SCHEMBL9027942 | 0.88 | TACR1 (0.65) | TACR2TACR1CCR5HRH1 | |
| Hydrochloric Acid SCHEMBL8591404 | 0.88 | TACR2 (0.53) | TACR2TACR1CCR5 | |
| SCHEMBL9032557 | 0.87 | TACR1 (0.65) | TACR2TACR1CCR5HRH1 | |
| SCHEMBL9028482 | 0.87 | TACR1 (0.65) | TACR2TACR1CCR5HRH1 | |
| SCHEMBL9028476 | 0.87 | TACR1 (0.65) | TACR2TACR1CCR5HRH1 | |
| SCHEMBL9028136 | 0.87 | TACR1 (0.65) | TACR2TACR1CCR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |