Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556171 | 0.88 | KCNN4 (0.52) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3503920 | 0.78 | KCNN4 (0.45) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL6325226 | 0.76 | KCNN4 (0.52) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL9740041 | 0.76 | KCNN4 (0.52) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL10408983 | 0.76 | KCNN4 (0.52) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3747207 | 0.76 | KCNN4 (0.52) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3320771 | 0.73 | KCNN4 (0.48) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL30541806 | 0.73 | CHRM2 (0.46) | KCNN4CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL18812594 | 0.72 | KIF11 (0.47) | KCNN4ALDH1A1KDM4E | |
| SCHEMBL2002478 | 0.71 | CA12 (0.42) | CHRM2CHRM1SIGMAR1OPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625514-B1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1999-08-25 | — | — | EP | disclosed |
| CN-1104637-A | Derivative of 2-aminopyrazine-5-carboxamide, preparation and pharmaceutical use of same | SYNTHELABO (FR) | 1995-07-05 | — | — | CN | disclosed |
| US-5420130-A | Adrenergic blocking agents | SYNTHELABO (FR) | 1995-05-30 | — | — | US | disclosed |
| EP-0625514-A1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-11-23 | — | — | EP | disclosed |