Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 17/20 | 0.70 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293111 | 0.91 | PLA2G2A (0.60) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL27365482 | 0.89 | PLA2G2A (0.56) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL8292611 | 0.89 | PLA2G2A (0.60) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL8292841 | 0.88 | PLA2G2A (0.60) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL5605448 | 0.88 | PLA2G2A (0.73) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL8292514 | 0.87 | PLA2G2A (0.75) | PLA2G2APLA2G1BKDM4ELMNAMAPT | |
| SCHEMBL8292054 | 0.87 | PLA2G2A (0.70) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL7963796 | 0.87 | PLA2G2A (0.60) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL7953677 | 0.87 | TDP1 (0.59) | PLA2G2APLA2G1BKDM4ELMNAGAA | |
| SCHEMBL8300494 | 0.86 | PLA2G2A (0.66) | PLA2G2APLA2G1BKDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |