Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301038 | 0.88 | PLA2G2A (0.71) | PLA2G2AGFERPTGDR2KDM4EGAA | |
| SCHEMBL8292611 | 0.88 | PLA2G2A (0.60) | PLA2G2AKDM4EGAALMNAMAPT | |
| SCHEMBL5605448 | 0.87 | PLA2G2A (0.73) | PLA2G2AKDM4EGAALMNAMAPT | |
| SCHEMBL9883461 | 0.87 | KDM4E (0.53) | PLA2G2AKDM4EGAALMNAALDH1A1 | |
| SCHEMBL8291608 | 0.86 | PLA2G2A (0.60) | PLA2G2AKDM4EGAALMNAMAPT | |
| SCHEMBL8300834 | 0.86 | PLA2G2A (0.70) | PLA2G2AKDM4EGAALMNAMAPT | |
| SCHEMBL7953677 | 0.86 | TDP1 (0.59) | PLA2G2AKDM4EGAALMNAMAPT | |
| SCHEMBL8293111 | 0.86 | PLA2G2A (0.60) | PLA2G2AKDM4EGAALMNAMAPT | |
| SCHEMBL7963796 | 0.86 | PLA2G2A (0.60) | PLA2G2AKDM4EGAALMNAMAPT | |
| SCHEMBL8292054 | 0.86 | PLA2G2A (0.70) | PLA2G2AKDM4EGAALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |