Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 16/20 | 0.74 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RGS12 | O14924 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8292855 | 0.93 | PLA2G2A (0.73) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8301080 | 0.91 | PLA2G2A (0.66) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL7962081 | 0.90 | PLA2G2A (0.80) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL7962138 | 0.89 | PLA2G2A (0.79) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8292902 | 0.89 | PLA2G2A (0.76) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8296825 | 0.89 | LMNA (0.66) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8292514 | 0.88 | PLA2G2A (0.75) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8291679 | 0.88 | PLA2G2A (0.76) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8296317 | 0.87 | LMNA (0.69) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8297277 | 0.87 | PLA2G2A (0.62) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |