SCHEMBL8301451

SCHEMBL8301451

Fc1nccc2c1CCCC2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.59
NOS1 P29475 1/20 0.59
NOS2 P35228 1/20 0.59
SIGMAR1 Q99720 1/20 0.40
BCL2L1 Q07817 1/20 0.38
BAD Q92934 1/20 0.38
CES1 P23141 3/20 0.36
LNPEP Q9UIQ6 2/20 0.33
CYP19A1 P11511 1/20 0.33
TSHR P16473 1/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.32
KDM4E B2RXH2 1/20 0.32
NAPRT Q6XQN6 1/20 0.31
RXRA P19793 1/20 0.31
RXRB P28702 1/20 0.31
RXRG P48443 1/20 0.31
KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2624104 0.74 NOS3 (0.59) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL8533330 0.74 NOS3 (0.59) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL27357146 0.74 NOS3 (0.59) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL394598 0.74 NOS2 (1.00) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL29386819 0.74 NOS3 (0.59) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL2624105 0.74 NOS3 (0.59) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL927218 0.74 NOS3 (0.53) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL21035410 0.72 NOS3 (0.57) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL25771762 0.72 NOS3 (0.57) NOS3NOS1NOS2SIGMAR1BCL2L1
SCHEMBL25795844 0.72 NOS3 (0.57) NOS3NOS1NOS2SIGMAR1BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824520-B1 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES HOECHST AG (DE) 1999-10-06 EP claimed
US-5942618-A 3,7-DISUBSTITUTED 1-FLUORO-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EXCELLENT LIGHT, CHEMICAL AND THERMAL STABILITY; COLORLESS IN PURE STATE; USE IN SWITCHING AND/OR DISPLAY DEVICE HOECHST AKTIENGESELLSCHAFT (DE) 1999-08-24 US claimed
EP-1773786-B1 FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-04-26 EP disclosed
EP-0824520-B1 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES HOECHST AG (DE) 1999-10-06 EP disclosed
EP-0824520-B1 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES HOECHST AG (DE) 1999-10-06 EP disclosed
US-5942618-A 3,7-DISUBSTITUTED 1-FLUORO-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EXCELLENT LIGHT, CHEMICAL AND THERMAL STABILITY; COLORLESS IN PURE STATE; USE IN SWITCHING AND/OR DISPLAY DEVICE HOECHST AKTIENGESELLSCHAFT (DE) 1999-08-24 US disclosed
US-5942618-A 3,7-DISUBSTITUTED 1-FLUORO-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EXCELLENT LIGHT, CHEMICAL AND THERMAL STABILITY; COLORLESS IN PURE STATE; USE IN SWITCHING AND/OR DISPLAY DEVICE HOECHST AKTIENGESELLSCHAFT (DE) 1999-08-24 US disclosed
US-5942618-A 3,7-DISUBSTITUTED 1-FLUORO-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EXCELLENT LIGHT, CHEMICAL AND THERMAL STABILITY; COLORLESS IN PURE STATE; USE IN SWITCHING AND/OR DISPLAY DEVICE HOECHST AKTIENGESELLSCHAFT (DE) 1999-08-24 US disclosed
EP-0824520-A1 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-25 EP disclosed
EP-0824520-A1 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-25 EP disclosed
WO-1996035675-A1 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-14 WO disclosed
WO-1996035675-A1 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-14 WO disclosed