Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 9/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | FCER2 | P06734 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389087 | 0.87 | PDPK1 (0.50) | PDPK1FCER2SYKKDRPDGFRB | |
| SCHEMBL1389131 | 0.85 | DHFR (0.52) | PDPK1FCER2SYKSRCPIM1 | |
| SCHEMBL8301615 | 0.84 | TLK2 (0.58) | TLK2PDPK1JAK3FCER2SYK | |
| SCHEMBL5201417 | 0.84 | PLK4 (0.62) | TLK2KDRPDGFRBPLK4PLK1 | |
| SCHEMBL7875966 | 0.80 | TLK2 (0.60) | TLK2PDPK1JAK3FCER2SYK | |
| SCHEMBL8099054 | 0.79 | PDPK1 (0.50) | PDPK1MEN1KMT2AKDRPDGFRB | |
| SCHEMBL8529177 | 0.79 | GSK3B (0.46) | TLK2MEN1KMT2AGSK3B | |
| SCHEMBL8099485 | 0.77 | DHFR (0.52) | PDPK1FCER2SYKMEN1KMT2A | |
| SCHEMBL8099022 | 0.77 | FLT3 (0.53) | CDK2MEN1KMT2AKDRSRC | |
| SCHEMBL8099047 | 0.77 | PLK4 (0.56) | MEN1KMT2ASRCPLK4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H08500847-A | — | — | 1996-01-30 | — | — | JP | claimed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | claimed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | claimed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | disclosed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | disclosed |