Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306967 | 0.83 | PDE3B (0.34) | PDE3BPDE3ACYP11B2CYP11B1 | |
| SCHEMBL8301776 | 0.81 | PDE3B (0.31) | PDE3BPDE3ACYP11B2CYP11B1 | |
| SCHEMBL8309068 | 0.80 | CYP11B1 (0.33) | CYP11B2CYP11B1 | |
| SCHEMBL8306110 | 0.78 | PDE3B (0.38) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL8303554 | 0.78 | PDE3B (0.38) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| Bromide SCHEMBL8301839 | 0.77 | PDE3B (0.38) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL8308168 | 0.76 | DRD2 (0.37) | — | |
| SCHEMBL8307863 | 0.76 | PDE3B (0.44) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL8303858 | 0.76 | CYP11B2 (0.47) | PDE3BPDE3ACYP11B2CYP11B1GRM4 | |
| SCHEMBL8304016 | 0.74 | PDE3B (0.36) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0548254-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004345-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |