Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.34 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588280 | 0.81 | PIM3 (0.50) | PIM3PIM1NR4A2KDM4EALDH1A1 | |
| SCHEMBL8307738 | 0.79 | BRD4 (0.48) | PIM3PIM1ALDH1A1HSD17B10BTK | |
| SCHEMBL8309106 | 0.78 | BRD4 (0.34) | ALDH1A1HSD17B10LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7497434 | 0.77 | PIM3 (0.55) | PIM3PIM1NUDT1NR4A2KDM4E | |
| SCHEMBL8303111 | 0.74 | PDE1A (0.39) | — | |
| SCHEMBL8306799 | 0.73 | CDK8 (0.39) | KDM4EALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2589245 | 0.73 | NR4A2 (0.60) | PIM3PIM1NUDT1NR4A2KDM4E | |
| SCHEMBL16174497 | 0.72 | MAPT (0.41) | KDM4EALDH1A1HSD17B10LMNAMAPT | |
| SCHEMBL14774594 | 0.72 | PIM3 (0.50) | PIM3PIM1NUDT1NR4A2KDM4E | |
| SCHEMBL22587514 | 0.72 | PIM3 (0.50) | PIM3PIM1NUDT1NR4A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| US-5281593-A | Pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |