Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.57 |
| ▸ | HTR1B | P28222 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.57 |
| ▸ | HTR6 | P50406 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125410 | 0.84 | HTR1D (0.59) | HTR1DHTR1BHTR2AHTR6HTR1A | |
| SCHEMBL8302847 | 0.78 | HTR1D (0.59) | HTR1DHTR1BHTR2AMAPTTUBB1 | |
| SCHEMBL8307059 | 0.76 | HTR1D (0.65) | HTR1DHTR1BHTR2AMAPTLMNA | |
| SCHEMBL7803371 | 0.73 | HTR1D (1.00) | HTR1DHTR1BHTR2AHTR6MAPT | |
| SCHEMBL9089296 | 0.72 | HTR1D (0.71) | HTR1DHTR1BHTR2ATMPRSS2SLC6A4 | |
| SCHEMBL6817232 | 0.72 | HTR1D (0.67) | HTR1DHTR1BHTR2AHTR6MAPT | |
| SCHEMBL8985970 | 0.71 | HTR1D (0.92) | HTR1DHTR1BHTR2AHTR6MAPT | |
| SCHEMBL8143971 | 0.70 | ALDH1A1 (0.41) | HTR1DHTR1BHTR2AHTR6MAPT | |
| SCHEMBL6817268 | 0.70 | HTR1D (0.61) | HTR1DHTR1BHTR2AHTR6MAPT | |
| SCHEMBL849340 | 0.69 | HPGD (0.59) | HTR1DHTR1BHTR2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716650-B1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-24 | — | — | EP | claimed |
| EP-0716650-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-19 | — | — | EP | claimed |
| WO-1995006637-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | claimed |
| EP-0716650-B1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-24 | — | — | EP | disclosed |
| US-5696122-A | Indole and indoline derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | disclosed |
| EP-0716650-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995006637-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | disclosed |