Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.71 |
| ▸ | HTR1B | P28222 | 3/20 | 0.71 |
| ▸ | HTR2A | P28223 | 3/20 | 0.71 |
| ▸ | WDR5 | P61964 | 8/20 | 0.55 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9332320 | 0.83 | HTR1D (0.56) | HTR1DHTR1BHTR2AWDR5TMPRSS2 | |
| SCHEMBL7803371 | 0.83 | HTR1D (1.00) | HTR1DHTR1BHTR2ATMPRSS2SLC6A4 | |
| SCHEMBL8985970 | 0.81 | HTR1D (0.92) | HTR1DHTR1BHTR2ATMPRSS2SLC6A4 | |
| SCHEMBL7803385 | 0.79 | HTR1D (0.69) | HTR1DHTR1BHTR2AWDR5TMPRSS2 | |
| SCHEMBL9301036 | 0.79 | HTR1D (0.82) | HTR1DHTR1BHTR2AWDR5TMPRSS2 | |
| SCHEMBL8302847 | 0.74 | HTR1D (0.59) | HTR1DHTR1BHTR2A | |
| SCHEMBL6817232 | 0.74 | HTR1D (0.67) | HTR1DHTR1BHTR2ATMPRSS2SLC6A4 | |
| SCHEMBL20605156 | 0.74 | WDR5 (0.70) | HTR1DHTR1BHTR2AWDR5 | |
| SCHEMBL9034453 | 0.73 | HTR1D (0.79) | HTR1DHTR1BHTR2ATMPRSS2SLC6A4 | |
| SCHEMBL8400880 | 0.73 | HTR1D (0.79) | HTR1DHTR1BHTR2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510350-A | USEFUL IN TREATMENT OR PROPHYLAXIS OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |
| US-5358948-A | Psychological, nervous system disorders | GLAXCO GROUP LIMITED (GB) | 1994-10-25 | — | — | US | disclosed |
| US-5340810-A | Useful in the treatment and prophylaxis of depression and other disorders of the central nervous system | GLAXO GROUP LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |
| WO-1993006084-A1 | BENZANILIDE DERIVATIVES AS 5-HT1D ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |
| EP-0533267-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| EP-0533268-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |