Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30780880 | 0.80 | PTGDR2 (0.46) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL3351674 | 0.80 | PTGDR2 (0.46) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL11237484 | 0.78 | KCNH2 (0.48) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL4448140 | 0.78 | KCNH2 (0.61) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL30707788 | 0.78 | KCNH2 (0.61) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL28365711 | 0.77 | KCNH2 (0.50) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL8305078 | 0.76 | FFAR1 (0.40) | FFAR1IDO1ALDH1A1 | |
| SCHEMBL18917798 | 0.75 | ALDH1A1 (0.47) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL30740911 | 0.75 | KCNH2 (0.46) | KCNH2PTGDR2GRM5FFAR1TSHR | |
| SCHEMBL4333048 | 0.75 | TP53 (0.39) | PTGDR2TSHRIDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749430-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5605918-A | SUBSTITUTED THIAZOLIDINE-2,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5574051-A | HYPOGLYCEMIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-11-12 | — | — | US | disclosed |
| WO-1995024400-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-14 | — | — | WO | disclosed |
| EP-0351194-B1 | Thiazole derivatives having a 5-lipoxygenase-inhibiting activity | ICI PLC (GB) | 1994-06-15 | — | — | EP | disclosed |
| US-5196422-A | Antiinflammatory agents, antiallergens | ICI PHARMA (FR) | 1993-03-23 | — | — | US | disclosed |
| US-5089513-A | Antiinflammatory agents; antiallergens; asthma; side effect reduction | ICI PHARMA (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0351194-A2 | Thiazole derivatives having a 5-lipoxygenase-inhibiting activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-01-17 | — | — | EP | disclosed |