Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175910 | 0.80 | CYP2C19 (0.50) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL29144735 | 0.80 | FFAR1 (0.42) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2466535 | 0.80 | FFAR1 (0.47) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL30468202 | 0.80 | FFAR1 (0.47) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL11174673 | 0.78 | FFAR1 (0.38) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL19302890 | 0.77 | ALDH1A1 (0.47) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL15353223 | 0.77 | TLR8 (0.45) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL436732 | 0.76 | MME (0.40) | TAAR1 | |
| SCHEMBL8307761 | 0.76 | TSHR (0.46) | FFAR1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8302074 | 0.76 | KCNH2 (0.44) | FFAR1ALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749430-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5605918-A | SUBSTITUTED THIAZOLIDINE-2,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5574051-A | HYPOGLYCEMIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-11-12 | — | — | US | disclosed |
| WO-1995024400-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-14 | — | — | WO | disclosed |