SCHEMBL8302409

SCHEMBL8302409

CC1=C(OC2CCCCO2)[C@@H](c2cccc([N+](=O)[O-])c2)C(C(=O)O)=C(C)N1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 8/20 0.50
CACNA1D Q01668 8/20 0.50
CACNA1S Q13698 8/20 0.50
CACNA1C Q13936 8/20 0.50
ADORA3 P0DMS8 1/20 0.50
CACNA1B Q00975 1/20 0.50
PDE1C Q14123 1/20 0.48
NR3C2 P08235 1/20 0.48
CYP1A2 P05177 4/20 0.47
CYP3A4 P08684 4/20 0.47
CYP2C9 P11712 4/20 0.47
CYP2C19 P33261 4/20 0.47
HIF1A Q16665 3/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
MAPT P10636 2/20 0.47
LMNA P02545 2/20 0.47
CYP2D6 P10635 2/20 0.47
TSHR P16473 2/20 0.47
NFKB1 P19838 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8301434 0.87 CACNA1C (0.57) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL3940339 0.79 CACNA1F (0.71) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL3032197 0.79 CACNA1F (0.71) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7416441 0.79 POLB (0.64) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL14565601 0.78 CACNA1F (0.59) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
Hydrochloric Acid SCHEMBL9374052 0.78 CACNA1F (0.70) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
Hydrochloric Acid SCHEMBL9374064 0.78 CACNA1F (0.70) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
Hydrochloric Acid SCHEMBL9805027 0.78 CACNA1F (0.70) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
Hydrochloric Acid SCHEMBL9805019 0.78 CACNA1F (0.70) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9765742 0.77 ABCB1 (0.64) CACNA1FCACNA1DCACNA1SCACNA1CADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636611-B1 Optically active 1,4-dihydropyridine derivatives and process for preparing the same MERCIAN CORP (JP) 1999-07-28 EP disclosed
US-5395941-A Optically active 1,4-hydropyridine compounds MERCIAN CORPORATION (JP) 1995-03-07 US disclosed
EP-0636611-A2 Optically active 1,4-dihydropyridine derivatives and process for preparing the same MERCIAN CORPORATION (JP) 1995-02-01 EP disclosed