Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304953 | 0.85 | PARP1 (0.39) | PARP1MMP12NR3C2ALDH1A1MAPT | |
| SCHEMBL8305659 | 0.78 | PARP1 (0.41) | PARP1MMP12NR3C2PKMALDH1A1 | |
| SCHEMBL8301749 | 0.78 | PARP1 (0.49) | PARP1MMP12NR3C2PKMALDH1A1 | |
| SCHEMBL8301836 | 0.74 | PARP1 (0.36) | PARP1MMP12NR3C2TRPV1 | |
| SCHEMBL3344322 | 0.73 | PARP1 (0.57) | PARP1MMP12NR3C2PKMALDH1A1 | |
| SCHEMBL8306241 | 0.72 | NR3C2 (0.48) | PARP1MMP12NR3C2PKMALDH1A1 | |
| SCHEMBL8303253 | 0.70 | PARP1 (0.36) | PARP1MMP12NR3C2ALDH1A1MAPT | |
| SCHEMBL8306817 | 0.70 | PARP1 (0.43) | PARP1MMP12NR3C2ALDH1A1MAPT | |
| SCHEMBL8308025 | 0.68 | PARP1 (0.45) | PARP1MMP12NR3C2PKMALDH1A1 | |
| SCHEMBL7844765 | 0.67 | GAA (0.36) | PARP1MMP12NR3C2PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0548254-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004345-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |