Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306997 | 0.88 | PARP1 (0.32) | PARP1DRD2DRD4DRD3 | |
| SCHEMBL8301738 | 0.81 | PARP1 (0.39) | PARP1NR3C2MMP12TRPV1DRD2 | |
| SCHEMBL8306003 | 0.78 | NR3C2 (0.38) | NR3C2MMP12DRD2DRD4DRD3 | |
| SCHEMBL8303332 | 0.77 | PARP1 (0.45) | PARP1NR3C2MMP12TRPV1DRD2 | |
| SCHEMBL8306912 | 0.76 | — | — | |
| SCHEMBL8307617 | 0.75 | PARP1 (0.45) | PARP1NR3C2MMP12TRPV1DRD2 | |
| SCHEMBL8308384 | 0.75 | DRD2 (0.37) | PARP1NR3C2MMP12DRD2DRD4 | |
| SCHEMBL8302723 | 0.74 | PARP1 (0.44) | PARP1NR3C2MMP12TRPV1 | |
| SCHEMBL8304593 | 0.72 | PARP1 (0.40) | PARP1NR3C2MMP12TRPV1DRD2 | |
| SCHEMBL8304724 | 0.70 | DRD2 (0.34) | PARP1NR3C2DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0548254-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004345-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |