Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21001383 | 0.82 | NR3C2 (0.47) | NR3C2MMP12PARP1PDE3BPDE3A | |
| SCHEMBL6432532 | 0.78 | NR3C2 (0.56) | NR3C2MMP12PARP1MAPTALDH1A1 | |
| SCHEMBL8302818 | 0.77 | NR3C2 (0.43) | NR3C2MMP12PARP1PDE3BPDE3A | |
| SCHEMBL17348473 | 0.76 | NR3C2 (0.57) | NR3C2MMP12PARP1TP53ALDH1A1 | |
| SCHEMBL3342262 | 0.73 | MMP12 (0.57) | MMP12PARP1PDE3BPDE3ATP53 | |
| SCHEMBL1285219 | 0.73 | MMP12 (0.45) | NR3C2MMP12PARP1PDE3BPDE3A | |
| SCHEMBL8306003 | 0.73 | NR3C2 (0.38) | NR3C2MMP12PDE3BPDE3ATP53 | |
| SCHEMBL8302723 | 0.72 | PARP1 (0.44) | NR3C2MMP12PARP1MAPTALDH1A1 | |
| SCHEMBL2953764 | 0.72 | MMP12 (0.64) | MMP12PARP1PDE3BPDE3ATP53 | |
| SCHEMBL14280509 | 0.71 | MMP12 (0.43) | NR3C2MMP12PARP1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0548254-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004345-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |