Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD4 | Q15561 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 2/20 | 0.43 |
| ▸ | FNTB | P49356 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989199 | 0.87 | ADRA2A (0.48) | ALDH1A1MAPTTDP1MEN1KMT2A | |
| SCHEMBL10695265 | 0.78 | TEAD4 (0.52) | TEAD4ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL83814 | 0.76 | TEAD4 (0.74) | TEAD4ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL83863 | 0.76 | TEAD4 (0.74) | TEAD4ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL95343 | 0.76 | TEAD4 (0.74) | TEAD4ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL21656832 | 0.76 | SRD5A2 (0.58) | MAPTKMT2AHDAC8HDAC6 | |
| SCHEMBL21656852 | 0.76 | CA12 (0.53) | ALDH1A1MAPTPOLBTDP1MEN1 | |
| SCHEMBL10030396 | 0.76 | TEAD4 (0.60) | TEAD4ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL4705880 | 0.76 | FFAR1 (0.53) | ALDH1A1MAPTTDP1ACHE | |
| SCHEMBL18409817 | 0.76 | TEAD4 (0.54) | TEAD4ALDH1A1MAPTPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |