SCHEMBL8302897

SCHEMBL8302897

O=C1C=NN=C(c2ccc(Cl)cc2)C1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.47
PDCD1 Q15116 1/20 0.37
CD274 Q9NZQ7 1/20 0.37
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
ALDH1A1 P00352 4/20 0.36
SMN1; SMN2 Q16637 4/20 0.36
KDM4E B2RXH2 3/20 0.36
MAPT P10636 4/20 0.35
GAA P10253 2/20 0.35
THRB P10828 1/20 0.35
TSHR P16473 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
NPSR1 Q6W5P4 2/20 0.33
LMNA P02545 1/20 0.33
ALPG P10696 1/20 0.33
ALOX12 P18054 1/20 0.33
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27753090 0.70 NOTUM (0.41) NOTUMNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL11185921 0.67 RECQL (0.41) NOTUMALDH1A1KDM4EMAPTGAA
SCHEMBL11528430 0.67 NOTUM (0.39) NOTUMNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL9782150 0.64 NOTUM (1.00) NOTUMPDCD1CD274NPC1RAB9A
SCHEMBL5561143 0.64 AXL (0.67) NOTUMNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL11531245 0.62 ALDH1A1 (0.38) NOTUMNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL11529919 0.62 MEN1 (0.40) NOTUMNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL7707656 0.62 ALDH1A1 (0.55) NOTUMPDCD1CD274NPC1RAB9A
SCHEMBL28631682 0.62 CYP1A2 (0.61) NOTUMNPC1RAB9AALDH1A1KDM4E
SCHEMBL261632 0.61 PDE3A (0.65) PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3661917-B1 6-((3-TRIFLUOROMETHYL)PHENYL)-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER BAYER AG (DE) 2022-05-11 EP disclosed
EP-0478195-B1 Dihydropyridazinones and pyridazinones as fungicides ROHM & HAAS (US) 1999-05-26 EP disclosed
US-5753642-A AGRICULTURE, MEDICINE ROHM AND HAAS COMPANY (US) 1998-05-19 US disclosed
US-5728694-A Dihydropyridazinones, pyridazinones and related compounds as fungicides ROHM AND HAAS COMPANY (US) 1998-03-17 US disclosed
US-5728698-A AGRICULTURAL USE, RICE, WHEAT ROHM AND HAAS COMPANY (US) 1998-03-17 US disclosed
US-5728715-A FOR MAMMALS, AGRICULTURE, RICE, WHEAT, TOMATOES ROHM AND HAAS COMPANY (US) 1998-03-17 US disclosed
US-5726176-A FOR CONTROLLING AGRICULTURAL AND MAMMALIAN FUNGAL DISEASES ROHM AND HAAS COMPANY (US) 1998-03-10 US disclosed
US-5726162-A FOR CONTROLLING AGRICULTURAL AND MAMMALIAN FUNGAL DISEASES ROHM AND HAAS COMPANY (US) 1998-03-10 US disclosed
US-5631254-A RICE; HUMAN INFECTIONS ROHM AND HAAS COMPANY (US) 1997-05-20 US disclosed
US-5552409-A PHYTOPATHOGENIC, RICE ROHM AND HAAS COMPANY (US) 1996-09-03 US disclosed
EP-0478195-A1 Dihydropyridazinones, pyridazinones and related compounds as fungicides ROHM AND HAAS COMPANY (US) 1992-04-01 EP disclosed