Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9314227 | 1.00 | LDHA (0.52) | LDHAMTNR1AMTNR1BALOX15ALOX12 | |
| SCHEMBL28888990 | 0.77 | MTNR1A (0.55) | LDHAMTNR1AMTNR1BALOX15ALOX12 | |
| SCHEMBL28888992 | 0.77 | MTNR1A (0.55) | LDHAMTNR1AMTNR1BALOX15ALOX12 | |
| SCHEMBL10771141 | 0.76 | LDHA (0.51) | LDHAMTNR1AMTNR1BALOX15ALOX12 | |
| SCHEMBL12485634 | 0.76 | LDHA (0.51) | LDHAMTNR1AMTNR1BALOX15ALOX12 | |
| SCHEMBL31489269 | 0.72 | LDHA (0.53) | LDHAALOX15ALOX12LMNAMMP1 | |
| SCHEMBL4277042 | 0.72 | MTNR1A (0.45) | LDHAMTNR1AMTNR1BALDH1A1CA2 | |
| SCHEMBL10728332 | 0.72 | MTNR1A (0.74) | LDHAMTNR1AMTNR1BALDH1A1NPC1 | |
| SCHEMBL14811706 | 0.72 | LDHA (0.52) | LDHAMTNR1AMTNR1BALOX15ALOX12 | |
| SCHEMBL1303120 | 0.71 | MTNR1A (0.54) | LDHAMTNR1AMTNR1BALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455006-B1 | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles | AMERICAN CYANAMID CO (US) | 1999-07-07 | — | — | EP | disclosed |
| US-5373020-A | Antidiabetic, antiobesity, hyperglycemic agents | AMERICAN CYANAMID COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| US-5245053-A | Resolution of diastereoisomers, reaction with Mosher's acid hypoglycemic agent, diabetes | AMERICAN CYANAMID COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| US-5151439-A | Antidiabetic agents or antihyperglycemic agents | AMERICAN CYANAMID COMPANY (US) | 1992-09-29 | — | — | US | disclosed |
| US-5106867-A | Administering substituted 1,3-benzodioxole antilipogenic agent | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0455006-A2 | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles | AMERICAN CYANAMID COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| US-5061727-A | ANTIOBESITY, ANTIDIABETIC, HYPOGLYCEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1991-10-29 | — | — | US | disclosed |