Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11893305 | 0.83 | MAOB (0.42) | HSD11B1MAOBMAOAALOX5APMEN1 | |
| SCHEMBL11028108 | 0.82 | ALOX5AP (0.48) | MAOBMAOAALOX5APKDM1ARCOR1 | |
| SCHEMBL87608 | 0.76 | HSD11B1 (0.55) | HSD11B1MAOBMAOAALOX5APMEN1 | |
| SCHEMBL1650476 | 0.71 | MAOB (0.54) | MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL3067375 | 0.70 | MAOB (0.52) | HSD11B1MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL83426 | 0.69 | HSD11B1 (0.45) | HSD11B1MAOBMAOAALOX5APMEN1 | |
| SCHEMBL13216349 | 0.68 | HSD11B1 (1.00) | HSD11B1MEN1KMT2A | |
| SCHEMBL807663 | 0.68 | ALOX5AP (0.55) | HSD11B1ALOX5AP | |
| SCHEMBL3054516 | 0.66 | MAOB (0.42) | MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL12954721 | 0.64 | ALOX5AP (0.63) | HSD11B1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735590-B2 | Bicyclo-heptan-2-amines | ADEJARE ADEBOYE (US) | 2014-05-27 | — | — | US | disclosed |
| US-8703799-B2 | Non-competitive NMDA receptor antagonists | ADEJARE ADEBOYE (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120190710-A1 | BICYCLO-HEPTAN-2-AMINES | Adeboye Adejare (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120129889-A1 | Non-competitive NMDA receptor antagonists | ADEJARE ADEBOYE (US) | 2012-05-24 | — | — | US | disclosed |
| US-8129414-B2 | Non-competitive NMDA receptor antagonists | Adejare, Adeboye (US) | 2012-03-06 | — | — | US | disclosed |
| US-20080039498-A1 | Non-competitive NMDA receptor antagonists | ADEJARE ADEBOYE | 2008-02-14 | — | — | US | disclosed |
| WO-2007149508-A2 | NON-COMPETITIVE NMDA RECEPTOR ANTAGONISTS | THE UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039498-A1 | Non-competitive NMDA receptor antagonists | GRIN1, GRIN3A, GRIN2A | HSD11B1 4199/4885MAOB 2190/4885MAOA 1452/4885 |
| US-20120190710-A1 | BICYCLO-HEPTAN-2-AMINES | SIGMAR1, HTR2A, HTR2C | HSD11B1 2984/4885MAOB 157/4885MAOA 205/4885 |
| US-20120129889-A1 | Non-competitive NMDA receptor antagonists | GRIN1, GRIN3A, GRIN2A | HSD11B1 4199/4885MAOB 2190/4885MAOA 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.