Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.54 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.45 |
| ▸ | ABCC2 | Q92887 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.45 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783716 | 1.00 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2CYP19A1MAOAMAOB | |
| SCHEMBL13513030 | 0.90 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2NPC1KDM4ELMNA | |
| SCHEMBL8303664 | 0.84 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2NPC1KDM4ELMNA | |
| SCHEMBL8303662 | 0.84 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2NPC1KDM4ELMNA | |
| SCHEMBL6796716 | 0.84 | CYSLTR2 (0.68) | CYSLTR1CYSLTR2CYP19A1MAOAMAOB | |
| SCHEMBL6796712 | 0.84 | CYSLTR2 (0.68) | CYSLTR1CYSLTR2CYP19A1MAOAMAOB | |
| SCHEMBL6750524 | 0.83 | KDM4E (0.67) | CYSLTR1CYSLTR2NPC1KDM4ELMNA | |
| SCHEMBL9757052 | 0.83 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2NPC1KDM4ELMNA | |
| SCHEMBL9757059 | 0.83 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2NPC1KDM4ELMNA | |
| SCHEMBL6990449 | 0.83 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2NPC1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773931-A1 | QUINOLINE DERIVATIVES AS LEUKOTRIENE ANTAGONISTS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1997-05-21 | — | — | EP | disclosed |
| EP-0654026-B1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1997-02-19 | — | — | EP | disclosed |
| US-5576438-A | LIPOXYGENASE INHIBITORS; ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktiesel Skab) (DK) | 1996-11-19 | — | — | US | disclosed |
| WO-1996002506-A1 | QUINOLINE DERIVATIVES AS LEUKOTRIENE ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-02-01 | — | — | WO | disclosed |
| EP-0654026-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003431-A1 | ISOSERINE DERIVATIVES AND THEIR USE AS LEUKOTRIENE ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-02-17 | — | — | WO | disclosed |