⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL10959290 | 0.97 | — | — | |
| SCHEMBL2016588 | 0.67 | CES2 (0.43) | — | |
| SCHEMBL771882 | 0.67 | CES2 (0.43) | — | |
| SCHEMBL422305 | 0.67 | — | — | |
| SCHEMBL14164313 | 0.67 | — | — | |
| SCHEMBL216983 | 0.63 | — | — | |
| SCHEMBL1718411 | 0.63 | CES2 (0.45) | — | |
| SCHEMBL10706711 | 0.63 | HSD17B1 (0.56) | — | |
| SCHEMBL2305406 | 0.62 | — | — | |
| SCHEMBL9454753 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1482122-A | Intermediates for producing 2-thiosubstituted carbapenems | 谷 | 2004-03-17 | — | — | CN | disclosed |
| CN-1136208-C | Intermediates for the preparation of 2-thiocarbpenems | 谷 | 2004-01-28 | — | — | CN | disclosed |
| CN-1223261-A | Novel 2-thiocarbpenems | AMERICAN CYANAMID CO (US) | 1999-07-21 | — | — | CN | disclosed |
| EP-0891339-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| CN-1041633-C | Novel 2-thiocarbpenems | AMERICAN CRANAMID CO (US) | 1999-01-13 | — | — | CN | disclosed |
| US-5859035-A | Arylheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997036881-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| CN-1104214-A | Novel 2-thiocarbpenems | AMERICAN CRANAMID COMPANY (US) | 1995-06-28 | — | — | CN | disclosed |