SCHEMBL8304145

SCHEMBL8304145

c1ccc2cc3c4c(ccc3cc2c1)C4

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.44
HSD17B10 Q99714 4/20 0.44
HIF1A Q16665 2/20 0.44
CYP1B1 Q16678 1/20 0.44
ANPEP P15144 1/20 0.39
KDM4E B2RXH2 2/20 0.37
GAA P10253 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
CYP3A4 P08684 1/20 0.37
ALOX15 P16050 1/20 0.37
CASP1 P29466 1/20 0.37
CASP7 P55210 1/20 0.37
HBB P68871 1/20 0.37
CYP1A2 P05177 3/20 0.36
ERBB2 P04626 1/20 0.36
FYN P06241 1/20 0.36
MAOA P21397 1/20 0.36
ACHE P22303 1/20 0.36
AHR P35869 1/20 0.36
CYP2A6 P11509 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31025685 0.98 ALDH1A1 (0.43) ALDH1A1HSD17B10HIF1ACYP1B1ANPEP
SCHEMBL2032513 0.81 ALDH1A1 (0.43) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL31690237 0.81 ALDH1A1 (0.43) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL29811500 0.79 ANPEP (0.55) ALDH1A1HSD17B10HIF1ACYP1B1ANPEP
SCHEMBL2535555 0.79 ANPEP (0.55) ALDH1A1HSD17B10HIF1ACYP1B1ANPEP
SCHEMBL31274510 0.79 ANPEP (0.55) ALDH1A1HSD17B10HIF1ACYP1B1ANPEP
SCHEMBL4851750 0.79 PNMT (0.42) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL30585506 0.79 PNMT (0.42) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL9845875 0.78 NQO1 (0.41) ALDH1A1HSD17B10HIF1ACYP1B1KDM4E
SCHEMBL19810085 0.78 ANPEP (0.46) ALDH1A1HSD17B10HIF1ACYP1B1ANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-52122358-A None JP disclosed
JP-52068170-A None JP disclosed
JP-52007953-A None JP disclosed
JP-5246988-A None JP disclosed
JP-5239026-A None JP disclosed
JP-51125269-A None JP disclosed
JP-51125373-A None JP disclosed
WO-2025056591-A1 FUNCTIONAL POLYMERS AND APPLICATIONS IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) 2025-03-20 WO disclosed
EP-0707579-B1 PIPERIDINYL SUBSTITUTED METHANOANTHRACENES AS D1/D2-ANTAGONISTS AND 5HT2-SEROTANIN-ANTAGONISTS ZENECA LTD (GB) 1999-01-20 EP disclosed
US-5719166-A TREATING PSYCHOSES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1998-02-17 US disclosed
EP-0533344-A1 Methanoanthracenes as dopamine antagonists ZENECA LIMITED (GB) 1993-03-24 EP disclosed
EP-0532177-A1 Methanoanthracenes as dopamine antagonists ZENECA LIMITED (GB) 1993-03-17 EP disclosed
EP-0532178-A1 Methanoanthracenes as dopamine antagonists ZENECA LIMITED (GB) 1993-03-17 EP disclosed
EP-0532178-A1 Methanoanthracenes as dopamine antagonists ZENECA LIMITED (GB) 1993-03-17 EP disclosed
EP-0532177-A1 Methanoanthracenes as dopamine antagonists ZENECA LIMITED (GB) 1993-03-17 EP disclosed
JP-S52122358-A NOVEL METHANO-ANTHRACENE DERIVATIVES SUMITOMO CHEM CO LTD 1977-10-14 JP disclosed
JP-S5268170-A PREPARATION OF NOVEL METHANO-ANTHRACENE DERIVATIVES SUMITOMO CHEM CO LTD 1977-06-06 JP disclosed
JP-S527953-A PREPARATION OF NOVEL METHANO-ANTHRACENE DERIVATIVES SUMITOMO CHEM CO LTD 1977-01-21 JP disclosed
JP-S51125373-A A PROCESS FOR PREPARING NOVEL METHANO-ANTHRACENE DERIVATINE SUMITOMO CHEM CO LTD 1976-11-01 JP disclosed
JP-S51125269-A PROCESS FOR PREPARING NEW METHANO- ANTHRACENE DERIVATIVES SUMITOMO CHEM CO LTD 1976-11-01 JP disclosed