Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17773178 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL7243647 | 0.70 | ALDH1A1 (0.70) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL121922 | 0.70 | ALDH1A1 (0.70) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL828241 | 0.69 | ALDH1A1 (0.64) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL17742727 | 0.69 | ALDH1A1 (0.64) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL11887259 | 0.69 | ALDH1A1 (0.58) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL8110667 | 0.69 | KDM4E (0.58) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL29583385 | 0.68 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL50542 | 0.68 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4EHPGDENPP2 | |
| SCHEMBL4595294 | 0.68 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4EHPGDENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915871-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004553-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F.HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |